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Study on Post-Treatment Relapse in HBeAg Positive CHB Patients

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Listed:
  • Junfeng Lu
  • Jin’e Li
  • Yali Liu
  • Shan Ren
  • Zhenhuan Cao
  • Yi Jin
  • Lina Ma
  • Chengli Shen
  • Xinyue Chen

Abstract

Background: Many factors are associated with post-treatment relapse in CHB patients, and there are no effective factors to predict relapse. In this study, we investigate the influence factors associated with post-treatment relapse and their predictive value in HBeAg positive CHB (eP-CHB). Methods: The factors associated with post-treatment relapse were analyzed firstly by a retrospective study in eP-CHB. Variables included age, sex, regimen, baseline HBeAg and HBV DNA level, total course of treatment as well as duration of consolidation therapy after HBeAg seroconversion. The predictive effects of the influence factors were evaluated in an eP-CHB prospective cohort. Results: 89 patients were enrolled in the retrospective study, 42(47.2%) relapsed after discontinuation of treatment. Factors related to post-treatment relapse were total course of treatment, duration of consolidation therapy and baseline HBV DNA level. Relapse rates in patients with total course >36 months, consolidation duration >12 months and baseline HBV DNA level 1.0E+7IU/ml (P = 0.01) respectively. Patients with HBV DNA≥1.0E+7IU/ml plus HBeAg

Suggested Citation

  • Junfeng Lu & Jin’e Li & Yali Liu & Shan Ren & Zhenhuan Cao & Yi Jin & Lina Ma & Chengli Shen & Xinyue Chen, 2015. "Study on Post-Treatment Relapse in HBeAg Positive CHB Patients," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0141072
    DOI: 10.1371/journal.pone.0141072
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