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24 versus 48 Weeks of Peginterferon Plus Ribavirin in Hepatitis C Virus Genotype 6 Chronically Infected Patients with a Rapid Virological Response: A Non-Inferiority Randomized Controlled Trial

Author

Listed:
  • Qingxian Cai
  • Xiaohong Zhang
  • Chaoshuang Lin
  • Xiaoqiong Shao
  • Yujuan Guan
  • Hong Deng
  • Min Wei
  • Mingshou Huang
  • Zefang Ren
  • Ling Lu
  • Yongyu Mei
  • Min Xu
  • Jianyun Zhu
  • Haiyan Shi
  • Guoli Lin
  • Ying Liu
  • Fengyu Hu
  • Qiumin Luo
  • Yun Lan
  • Fengxia Guo
  • Zhixin Zhao
  • Zhiliang Gao

Abstract

Objectives: The optimal treatment of hepatitis C virus (HCV) genotype 6 is unclear owing to its limited geographic distribution. Because of a high predictive value of rapid virological response (RVR) for sustained virological response (SVR), we conducted an open-label randomized controlled trial to compare 24- and 48-week peginterferon/ribavirin combination therapy for patients with HCV genotype 6 in Southern China who achieved an RVR. Methods and Findings: Treatment-naive, non-cirrhotic patients with chronic hepatitis C genotype 6 were treated with pegylated interferon α-2a (180 μg/week) and ribavirin (800–1,200 mg, according to weight) for 4 weeks. Patients who achieved an RVR, which was defined as HCV RNA negativity at week 4 (

Suggested Citation

  • Qingxian Cai & Xiaohong Zhang & Chaoshuang Lin & Xiaoqiong Shao & Yujuan Guan & Hong Deng & Min Wei & Mingshou Huang & Zefang Ren & Ling Lu & Yongyu Mei & Min Xu & Jianyun Zhu & Haiyan Shi & Guoli Lin, 2015. "24 versus 48 Weeks of Peginterferon Plus Ribavirin in Hepatitis C Virus Genotype 6 Chronically Infected Patients with a Rapid Virological Response: A Non-Inferiority Randomized Controlled Trial," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-14, October.
    • Handle: RePEc:plo:pone00:0140853
    DOI: 10.1371/journal.pone.0140853
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