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Relationship between Polycystic Ovarian Syndrome and Subsequent Gestational Diabetes Mellitus: A Nationwide Population-Based Study

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  • Mei-Lien Pan
  • Li-Ru Chen
  • Hsiao-Mei Tsao
  • Kuo-Hu Chen

Abstract

Objective: This nationwide population-based study aims to explore the relationship between polycystic ovarian syndrome (PCOS) and subsequent gestational diabetes mellitus (GDM). Methods: Data from 1998–2012 Taiwan National Health Insurance Research Database were used for this study. ICD9-CM codes 256.4X and 648.X were used separately for the diagnoses of PCOS and GDM, which were further confirmed by records of blood tests or ultrasonography to ensure the accuracy of the diagnoses. Women diagnosed at 45 years of age, and those diagnosed with overt diabetes mellitus or GDM prior to PCOS were excluded. During pregnancy, each woman with a previous diagnosis of PCOS was age-matched to 10 women without PCOS. Odds ratios (ORs) for risk of GDM were calculated by logistic regression analysis with adjustment for economic status and co-morbidities. Results: Among 7,629 eligible women with a valid PCOS diagnosis, 3,109 (42.87%) had subsequent pregnancies. GDM occurred frequently among women with a history of PCOS as compared to those without PCOS (20.46% vs. 10.54%, p 0.05). If not used after conception, OHAs did not reduce the risk of GDM (adjusted OR = 1.20; 95% CI:0.88–1.62). Conclusions: A history of PCOS is a significant and independent risk factor for development of GDM. Medication for PCOS or pre-pregnancy use of OHAs does not reduce the risk of GDM. When at-risk women become pregnant, they require closer surveillance for maternal and fetal well-being, and should follow a strict diet and adhere to weight gain control to avoid obstetric complications due to GDM.

Suggested Citation

  • Mei-Lien Pan & Li-Ru Chen & Hsiao-Mei Tsao & Kuo-Hu Chen, 2015. "Relationship between Polycystic Ovarian Syndrome and Subsequent Gestational Diabetes Mellitus: A Nationwide Population-Based Study," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-9, October.
  • Handle: RePEc:plo:pone00:0140544
    DOI: 10.1371/journal.pone.0140544
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    Cited by:

    1. Juan Juan & Huixia Yang, 2020. "Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China," IJERPH, MDPI, vol. 17(24), pages 1-14, December.
    2. Hsiu-Nien Shen & Sheng-Yuan Hua & Chang-Ta Chiu & Chung-Yi Li, 2017. "Maternal Exposure to Air Pollutants and Risk of Gestational Diabetes Mellitus in Taiwan," IJERPH, MDPI, vol. 14(12), pages 1-12, December.
    3. Mei-Lien Pan & Li-Ru Chen & Hsiao-Mei Tsao & Kuo-Hu Chen, 2017. "Risk of gestational hypertension-preeclampsia in women with preceding endometriosis: A nationwide population-based study," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-13, July.

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