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Diagnostic Ureterorenoscopy Is Associated with Increased Intravesical Recurrence following Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma

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  • Hyun Hwan Sung
  • Hwang Gyun Jeon
  • Deok Hyun Han
  • Byong Chang Jeong
  • Seong Il Seo
  • Hyun Moo Lee
  • Han-Yong Choi
  • Seong Soo Jeon

Abstract

Diagnostic ureterorenoscopy is powerful tool to confirm upper tract urothelial cancer (UTUC). However, URS and associated manipulation may be related to the risk of intravesical recurrence (IVR) following radical nephroureterectomy (RNU). We aimed to investigate whether preoperative ureterorenoscopy would increase IVR after RNU in patients with UTUC. We performed a retrospective analysis of 630 patients who had RNU with bladder cuff excision due to UTUC. Diagnostic URS was performed in 282 patients (44.7%). Patients were divided into two groups according to the URS. Survival analysis and multivariate Cox regression model were performed to address risk factors for the IVR. The interval from URS to RNU was measured. During URS, manipulation such as biopsy and resection was determined. The median age was 64 (IQR 56–72) years with follow-up duration of 34.3 (15.7–64.9) months. Median time from URS to RNU was 16 (0–38) days. The IVR developed in 42.5% (n = 268) patients at 8.2 (4.9–14.7) months. The five-year IVR-free survival rate was 42.6 ± 8.0% and 63.6 ± 6.9% in patients with and without preoperative URS, respectively (P

Suggested Citation

  • Hyun Hwan Sung & Hwang Gyun Jeon & Deok Hyun Han & Byong Chang Jeong & Seong Il Seo & Hyun Moo Lee & Han-Yong Choi & Seong Soo Jeon, 2015. "Diagnostic Ureterorenoscopy Is Associated with Increased Intravesical Recurrence following Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0139976
    DOI: 10.1371/journal.pone.0139976
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