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Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China

Author

Listed:
  • Shui-Ming Guo
  • Min Han
  • Mei-Xue Chen
  • Yong Ning
  • Guang-Chang Pei
  • Yue-Qiang Li
  • Wei Dai
  • Shu-Wang Ge
  • Yuan-Jun Deng
  • Yan-Yan Guo
  • Xiao-Qing Li
  • Hermann Haller
  • Gang Xu
  • Song Rong

Abstract

Background: Soluble urokinase receptor (suPAR) may be involved in the pathological mechanisms of focal segmental glomerulosclerosis (FSGS) changes. However, it remains unclear whether suPAR is correlated with the FSGS-like lesions in IgA nephropathy (IgAN). Methods: We measured the plasma suPAR levels in 138 patients with IgAN, and then their clinical and pathological relationships were analyzed. Results: We found that the plasma suPAR levels were significantly correlated with age and renal function by both univariate and multivariate analysis in our IgAN patient cohort. Female had higher plasma suPAR levels and no significant correlation was observed between plasma suPAR levels and 24-h urine protein and highly sensitive C-reaction protein with multivariate analysis. In our cohort, sixty of these IgAN patients could be diagnosed with a type of FSGS lesions. The plasma suPAR levels were higher in the IgAN patients with FSGS lesions than in the IgAN patients without FSGS lesions by univariate (P

Suggested Citation

  • Shui-Ming Guo & Min Han & Mei-Xue Chen & Yong Ning & Guang-Chang Pei & Yue-Qiang Li & Wei Dai & Shu-Wang Ge & Yuan-Jun Deng & Yan-Yan Guo & Xiao-Qing Li & Hermann Haller & Gang Xu & Song Rong, 2015. "Soluble Urokinase Receptor Levels Are Correlated with Focal Segmental Glomerulosclerosis Lesions in IgA Nephropathy: A Cohort Study from China," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-15, September.
    • Handle: RePEc:plo:pone00:0138718
    DOI: 10.1371/journal.pone.0138718
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