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Outcomes of Technical Variant Liver Transplantation versus Whole Liver Transplantation for Pediatric Patients: A Meta-Analysis

Author

Listed:
  • Hui Ye
  • Qiang Zhao
  • Yufang Wang
  • Dongping Wang
  • Zhouying Zheng
  • Paul Michael Schroder
  • Yao Lu
  • Yuan Kong
  • Wenhua Liang
  • Yushu Shang
  • Zhiyong Guo
  • Xiaoshun He

Abstract

Objective: To overcome the shortage of appropriate-sized whole liver grafts for children, technical variant liver transplantation has been practiced for decades. We perform a meta-analysis to compare the survival rates and incidence of surgical complications between pediatric whole liver transplantation and technical variant liver transplantation. Methods: To identify relevant studies up to January 2014, we searched PubMed/Medline, Embase, and Cochrane library databases. The primary outcomes measured were patient and graft survival rates, and the secondary outcomes were the incidence of surgical complications. The outcomes were pooled using a fixed-effects model or random-effects model. Results: The one-year, three-year, five-year patient survival rates and one-year, three-year graft survival rates were significantly higher in whole liver transplantation than technical variant liver transplantation (OR = 1.62, 1.90, 1.65, 1.78, and 1.62, respectively, p

Suggested Citation

  • Hui Ye & Qiang Zhao & Yufang Wang & Dongping Wang & Zhouying Zheng & Paul Michael Schroder & Yao Lu & Yuan Kong & Wenhua Liang & Yushu Shang & Zhiyong Guo & Xiaoshun He, 2015. "Outcomes of Technical Variant Liver Transplantation versus Whole Liver Transplantation for Pediatric Patients: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0138202
    DOI: 10.1371/journal.pone.0138202
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