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Reproducibility of Volumetric Computed Tomography of Stable Small Pulmonary Nodules with Implications on Estimated Growth Rate and Optimal Scan Interval

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  • Gary T Smith
  • Ahmad R Rahman
  • Ming Li
  • Brandon Moore
  • Hester Gietema
  • Giulia Veronesi
  • Pierre P Massion
  • Ronald C Walker

Abstract

Purpose: To use clinically measured reproducibility of volumetric CT (vCT) of lung nodules to estimate error in nodule growth rate in order to determine optimal scan interval for patient follow-up. Methods: We performed quantitative vCT on 89 stable non-calcified nodules and 49 calcified nodules measuring 3–13 mm diameter in 71 patients who underwent 3–9 repeat vCT studies for clinical evaluation of pulmonary nodules. Calculated volume standard deviation as a function of mean nodule volume was used to compute error in estimated growth rate. This error was then used to determine the optimal patient follow-up scan interval while fixing the false positive rate at 5%. Results: Linear regression of nodule volume standard deviation versus the mean nodule volume for stable non-calcified nodules yielded a slope of 0.057±0.002 (r2 = 0.79, p

Suggested Citation

  • Gary T Smith & Ahmad R Rahman & Ming Li & Brandon Moore & Hester Gietema & Giulia Veronesi & Pierre P Massion & Ronald C Walker, 2015. "Reproducibility of Volumetric Computed Tomography of Stable Small Pulmonary Nodules with Implications on Estimated Growth Rate and Optimal Scan Interval," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0138144
    DOI: 10.1371/journal.pone.0138144
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