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MUC1 Predicts Colorectal Cancer Metastasis: A Systematic Review and Meta-Analysis of Case Controlled Studies

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Listed:
  • Yunhui Zeng
  • Qiongwen Zhang
  • Yujie Zhang
  • Minxun Lu
  • Yang Liu
  • Tianying Zheng
  • Shijian Feng
  • Meiqin Hao
  • Huashan Shi

Abstract

Objective: To evaluate the predicting value of MUC1 expression in lymph node and distant metastasis of colorectal cancer (CRC). Methods: Pubmed/ MEDLINE and EMBASE were searched to identify eligible studies that evaluated the correlation between MUC1 and CRC. A meta-analysis was conducted to evaluate the impact of MUC1 expression on CRC metastasis. Results: A total of 18 studies (n = 3271) met inclusion criteria and the mean Newcastle-Ottawa Scale (NOS) score was 6.3 with a range from 4 to 8. The pooled OR in the meta-analysis of 15 studies indicated that positive MUC1 expression correlated with more CRC node metastasis (OR = 2.32, 95% CI = 1.63–3.29). The data synthesis of 6 studies suggested that MUC1 expression predicted more possibility of CRC distant metastasis (OR = 2.22, 95% CI = 1.23–4.00). In addition, the combined OR of 7 studies showed that MUC1 expression indicated higher Duke’s stage (OR = 3.02, 95% CI = 2.11–4.33). No publication bias was found in the mate-analysis by Begg’s test or Egger’s test with the exception of the meta-analysis of MUC1 with CRC node metastasis (Begg’s test p = 0.729, Egger’s test p = 0.000). Conclusions: Despite of some modest bias, the pooled evidence suggested that MUC1 expression was significantly correlated with CRC metastasis.

Suggested Citation

  • Yunhui Zeng & Qiongwen Zhang & Yujie Zhang & Minxun Lu & Yang Liu & Tianying Zheng & Shijian Feng & Meiqin Hao & Huashan Shi, 2015. "MUC1 Predicts Colorectal Cancer Metastasis: A Systematic Review and Meta-Analysis of Case Controlled Studies," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-17, September.
    • Handle: RePEc:plo:pone00:0138049
    DOI: 10.1371/journal.pone.0138049
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