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Higher Decorin Levels in Bone Marrow Plasma Are Associated with Superior Treatment Response to Novel Agent-Based Induction in Patients with Newly Diagnosed Myeloma - A Retrospective Study

Author

Listed:
  • Shang-Yi Huang
  • Hsiu-Hsia Lin
  • Ming Yao
  • Jih-Luh Tang
  • Shang-Ju Wu
  • Hsin-An Hou
  • Wen-Chien Chou
  • Sheng-Chieh Chou
  • Szu-Chun Hsu
  • Bor-Sheng Ko
  • Hsiao-Yun Lu
  • Woei Tsay
  • Hwei-Fang Tien

Abstract

The growth of myeloma cells depends on bone marrow (BM) stroma consisting of stromal cells, secreted cytokines and the extracellular matrix (ECM). Decorin, a small leucine-rich proteoglycan in the ECM, is a signaling ligand and native anti-tumor agent. However, the role of decorin in patients with myeloma is not clear. We evaluated the correlation between the decorin levels measured by enzyme-linked immunosorbent assay in BM plasma from 121 patients with newly diagnosed myeloma based on their clinical features and treatment response. The median decorin levels in the patients and the normal control group were 12.31 ng/mL [standard deviation (SD), 7.50 ng/mL; range, 2.45 to 44.46 ng/mL] and 10.31 ng/mL (SD, 2.42 ng/mL; range, 4.85–15.14 ng/mL), respectively (P

Suggested Citation

  • Shang-Yi Huang & Hsiu-Hsia Lin & Ming Yao & Jih-Luh Tang & Shang-Ju Wu & Hsin-An Hou & Wen-Chien Chou & Sheng-Chieh Chou & Szu-Chun Hsu & Bor-Sheng Ko & Hsiao-Yun Lu & Woei Tsay & Hwei-Fang Tien, 2015. "Higher Decorin Levels in Bone Marrow Plasma Are Associated with Superior Treatment Response to Novel Agent-Based Induction in Patients with Newly Diagnosed Myeloma - A Retrospective Study," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0137552
    DOI: 10.1371/journal.pone.0137552
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