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Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients

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  • Caroline M J Loos
  • Pim Klarenbeek
  • Robert J van Oostenbrugge
  • Julie Staals

Abstract

Objectives: Perivascular spaces are associated with MRI markers of cerebral small vessel disease, including white matter hyperintensities. Although perivascular spaces are considered to be an early MRI marker of cerebral small vessel disease, it is unknown whether they are associated with further progression of MRI markers, especially white matter hyperintensities. We determined the association between perivascular spaces and progression of white matter hyperintensities after 2-year follow-up in lacunar stroke patients. Methods: In 118 lacunar stroke patients we obtained brain MRI and 24-hour ambulatory blood pressure measurements at baseline, and a follow-up brain MRI 2 years later. We visually graded perivascular spaces and white matter hyperintensities at baseline. Progression of white matter hyperintensities was assessed using a visual white matter hyperintensity change scale. Associations with white matter hyperintensity progression were tested with binary logistic regression analysis. Results: Extensive basal ganglia perivascular spaces were associated with progression of white matter hyperintensities (OR 4.29; 95% CI: 1.28–14.32; p

Suggested Citation

  • Caroline M J Loos & Pim Klarenbeek & Robert J van Oostenbrugge & Julie Staals, 2015. "Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-10, September.
    • Handle: RePEc:plo:pone00:0137323
    DOI: 10.1371/journal.pone.0137323
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