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Hypoxaemia as a Mortality Risk Factor in Acute Lower Respiratory Infections in Children in Low and Middle-Income Countries: Systematic Review and Meta-Analysis

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  • Marzia Lazzerini
  • Michela Sonego
  • Maria Chiara Pellegrin

Abstract

Objective: To evaluate the association between hypoxaemia and mortality from acute lower respiratory infections (ALRI) in children in low- and middle-income countries (LMIC). Design: Systematic review and meta-analysis. Study Selection: Observational studies reporting on the association between hypoxaemia and death from ALRI in children below five years in LMIC. Data Sources: Medline, Embase, Global Health Library, Lilacs, and Web of Science to February 2015. Risk of Bias Assessment: Quality In Prognosis Studies tool with minor adaptations to assess the risk of bias; funnel plots and Egger’s test to evaluate publication bias. Results: Out of 11,627 papers retrieved, 18 studies from 13 countries on 20,224 children met the inclusion criteria. Twelve (66.6%) studies had either low or moderate risk of bias. Hypoxaemia defined as oxygen saturation rate (SpO2)

Suggested Citation

  • Marzia Lazzerini & Michela Sonego & Maria Chiara Pellegrin, 2015. "Hypoxaemia as a Mortality Risk Factor in Acute Lower Respiratory Infections in Children in Low and Middle-Income Countries: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-17, September.
    • Handle: RePEc:plo:pone00:0136166
    DOI: 10.1371/journal.pone.0136166
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