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Asthma and COPD Overlap Syndrome (ACOS): A Systematic Review and Meta Analysis

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  • A Alshabanat
  • Z Zafari
  • O Albanyan
  • M Dairi
  • J M FitzGerald

Abstract

Background: The combination of asthma and chronic obstructive pulmonary disease (COPD), or ACOS is a recently defined syndrome. The epidemiology of the condition is poorly described and previous research has suggested ACOS is associated with worse outcomes than either condition alone. We therefore decided to complete a systematic review of the published literature. Methods: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta- Analyses guidelines. A structured search was performed in the PubMed, Embase, and Medline databases up to Feb 2015 to identify studies reporting incidence, prevalence, health care utilization, morbidity, or mortality in COPD and asthma. Results: A total of 19 studies were included in the present study. The pooled prevalence of overlap among COPD was 27% (95% CI: 0.16–0.38, p

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  • A Alshabanat & Z Zafari & O Albanyan & M Dairi & J M FitzGerald, 2015. "Asthma and COPD Overlap Syndrome (ACOS): A Systematic Review and Meta Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-15, September.
    • Handle: RePEc:plo:pone00:0136065
    DOI: 10.1371/journal.pone.0136065
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