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Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis

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Listed:
  • Zhenqiang Sun
  • Ruiwei Xu
  • Xiayu Li
  • Weiguo Ren
  • Chunlin Ou
  • Qisan Wang
  • Han Zhang
  • Xuemei Zhang
  • Jian Ma
  • Haijiang Wang
  • Guiyuan Li

Abstract

Background: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which is critical for regulating organ size, cell proliferation and tumor growth in mammals. Many previous studies have explored the relationship between YAP1 and various types of cancer. However, these studies were limited by the small samples size and the findings were inconsistent among them. Therefore, a meta-analysis was conducted to assess the association between YAP1 and malignancies. Methods: A systematic literature search was conducted for eligible studies in the PubMed, Corchane Library, Web of Knowledge, EMBASE and CBM disc databases from inception to August 1st 2014. After heterogeneity analysis, pooled harzad ratio (HR) with 95% confidence interval (95%CI) using both fixed and random effect models were estimated in STATA 10.0. Meta regression analysis, subgroup analysis and sensitivity analysis were performed to explore the potential sources of heterogeneity and to evaluate the robustness of the result. Publication bias was assessed by Egger’s test and funnel plot. Results: A total of 21 unique articles from 2009 to 2014, comprising 2983 patients, were analyzed in the meta-analysis. The association of YAP1 expression and overall survival time (OS) was evaluated in 20 studies including 2067 patients. Positive YAP1 showed poorer OS (HR = 1.826; 95% CI = 1.465–2.275; p

Suggested Citation

  • Zhenqiang Sun & Ruiwei Xu & Xiayu Li & Weiguo Ren & Chunlin Ou & Qisan Wang & Han Zhang & Xuemei Zhang & Jian Ma & Haijiang Wang & Guiyuan Li, 2015. "Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-17, August.
    • Handle: RePEc:plo:pone00:0135119
    DOI: 10.1371/journal.pone.0135119
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    1. Evan R. Barry & Teppei Morikawa & Brian L. Butler & Kriti Shrestha & Rosemarie de la Rosa & Kelley S. Yan & Charles S. Fuchs & Scott T. Magness & Ron Smits & Shuji Ogino & Calvin J. Kuo & Fernando D. , 2013. "Restriction of intestinal stem cell expansion and the regenerative response by YAP," Nature, Nature, vol. 493(7430), pages 106-110, January.
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