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The Screening Performance of Serum 1,3-Beta-D-Glucan in Patients with Invasive Fungal Diseases: A Meta-Analysis of Prospective Cohort Studies

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  • Tie-Ying Hou
  • Shou-Hong Wang
  • Sui-Xin Liang
  • Wen-Xin Jiang
  • Dan-Dong Luo
  • De-Hong Huang

Abstract

The serum 1,3-beta-D-glucan (BG) assay aids in the early diagnosis of invasive fungal diseases (IFDs) and has been approved for their diagnosis. However, reports on the screening performance of BG are scarce. We performed a meta-analysis of data extracted from only prospective cohort studies to evaluate the screening performance of the BG assay in the diagnosis of IFDs. We specifically searched 4 databases (the PubMed, Web of Science, Elsevier, and Cochrane Collaboration databases) according to EORTC-MSG criteria. A total of 1068 patients in 11 studies were analyzed. Deeks’ funnel plot asymmetry test suggested a low likelihood of publication bias for the included studies (p = 0.055). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic curve, with 95% confidence intervals, were 0.75(0.63,0.84), 0.87(0.81,0.92), 5.85(3.96,8.63), 0.30(0.20,0.45), 19.53(11.16,34.18), and 0.89(0.86,0.91), respectively. The findings of this meta-analysis suggest that the BG assay is a useful screening tool with high sensitivity and specificity for discriminating between patients with and without IFDs. In clinical practice, BG assay results should be evaluated together with clinical and microbiological findings.

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  • Tie-Ying Hou & Shou-Hong Wang & Sui-Xin Liang & Wen-Xin Jiang & Dan-Dong Luo & De-Hong Huang, 2015. "The Screening Performance of Serum 1,3-Beta-D-Glucan in Patients with Invasive Fungal Diseases: A Meta-Analysis of Prospective Cohort Studies," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0131602
    DOI: 10.1371/journal.pone.0131602
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    Cited by:

    1. Elena De Carolis & Federica Marchionni & Riccardo Torelli & Morandotti Grazia Angela & Livio Pagano & Rita Murri & Gennaro De Pascale & Giulia De Angelis & Maurizio Sanguinetti & Brunella Posteraro, 2020. "Comparative performance evaluation of Wako β-glucan test and Fungitell assay for the diagnosis of invasive fungal diseases," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-12, July.

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