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Clinical Factors and Viral Load Influencing Severity of Acute Hepatitis A

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  • Hyun Woong Lee
  • Dong-Yeop Chang
  • Hong Ju Moon
  • Hye Young Chang
  • Eui-Cheol Shin
  • June Sung Lee
  • Kyung-Ah Kim
  • Hyung Joon Kim

Abstract

Background and Aims: Clinical manifestations of hepatitis A virus (HAV) infection vary from mild to fulminant hepatic failure (FHF) in adults. We investigated the relationship between laboratory findings, including viral load, and clinical outcomes in patients with acute hepatitis A (AHA) and evaluated predictive factors for severe acute hepatitis (s-AH). Methods: We analyzed the clinical manifestations of AHA in 770 patients. Patients with a prothrombin time (PT) of less than 40% of normal were classified as s-AH and included 4 patients with FHF, 11 patients with acute renal failure, and 3 patients with prolonged jaundice (n = 128). Other patients were defined as mild acute hepatitis (m-AH) (n = 642). Serum samples were obtained from 48 patients with acute hepatitis A. Among them, 20 with s-AH, and 28 with m-AH, were tested for HAV RNA titer. Results: In a multivariate analysis, age (HR = 1.042, P = 0.041), peak creatinine (HR = 4.014, P = 0.001), bilirubin (HR = 1.153, P = 0.003), alanine aminotransferase (ALT) (HR = 1.001, P

Suggested Citation

  • Hyun Woong Lee & Dong-Yeop Chang & Hong Ju Moon & Hye Young Chang & Eui-Cheol Shin & June Sung Lee & Kyung-Ah Kim & Hyung Joon Kim, 2015. "Clinical Factors and Viral Load Influencing Severity of Acute Hepatitis A," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0130728
    DOI: 10.1371/journal.pone.0130728
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    1. Desenclos, J.-C.A. & Klontz, K.C. & Wilder, M.H. & Nainan, O.V. & Margolis, H.S. & Gunn, R.A., 1991. "A multistate outbreak of hepatitis A caused by the consumption of raw oysters," American Journal of Public Health, American Public Health Association, vol. 81(10), pages 1268-1272.
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