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Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis

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  • You-Lin Wang
  • Bo Jiang
  • Fu-Fen Yin
  • Hao-Qing Shi
  • Xiao-Dong Xu
  • Shuai-Shuai Zheng
  • Shuai Wu
  • Si-Chuan Hou

Abstract

Background: Multiple studies have investigated the effect of perioperative blood transfusion (PBT) for patients with radical cystectomy (RC), but the results have been inconsistent. We conducted a systematic review and meta-analysis to investigate the relationship between PBT and the clinical outcomes of RC patients. Methods: We searched MEDLINE, EMBASE, the Cochrane library and BIOSIS previews to identify relevant literature for studies that focused on the relationship of PBT and outcomes of patients undergoing RC. A fixed or random effects model was used in this meta-analysis to calculate the pooled hazard ratio (HR) with 95% confidence intervals (CIs). Results: A total of 7080 patients in 6 studies matched the selection criteria. Aggregation of the data suggested that PBT in patients who underwent RC correlated with increased all-cause mortality, cancer-specific mortality and cancer recurrence. The combined HRs were 1.19 (n = 6 studies, 95% CI: 1.11–1.27, Z = 4.71, P

Suggested Citation

  • You-Lin Wang & Bo Jiang & Fu-Fen Yin & Hao-Qing Shi & Xiao-Dong Xu & Shuai-Shuai Zheng & Shuai Wu & Si-Chuan Hou, 2015. "Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0130122
    DOI: 10.1371/journal.pone.0130122
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    References listed on IDEAS

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    1. Lei Liu & Zhiwei Wang & Songqi Jiang & Bingfeng Shao & Jibing Liu & Suqing Zhang & Yilong Zhou & Yuan Zhou & Yixin Zhang, 2013. "Perioperative Allogenenic Blood Transfusion Is Associated with Worse Clinical Outcomes for Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
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