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Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus

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  • Sharon A Chung
  • Joanne Nititham
  • Emon Elboudwarej
  • Hong L Quach
  • Kimberly E Taylor
  • Lisa F Barcellos
  • Lindsey A Criswell

Abstract

Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies associated with specific clinical manifestations. Previous studies have shown an association between differential DNA methylation and SLE susceptibility, but have not investigated SLE-related autoantibodies. Our goal was to determine whether DNA methylation is associated with production of clinically relevant SLE-related autoantibodies, with an emphasis on the anti-dsDNA autoantibody. In this study, we characterized the methylation status of 467,314 CpG sites in 326 women with SLE. Using a discovery and replication study design, we identified and replicated significant associations between anti-dsDNA autoantibody production and the methylation status of 16 CpG sites (pdiscovery

Suggested Citation

  • Sharon A Chung & Joanne Nititham & Emon Elboudwarej & Hong L Quach & Kimberly E Taylor & Lisa F Barcellos & Lindsey A Criswell, 2015. "Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-16, July.
    • Handle: RePEc:plo:pone00:0129813
    DOI: 10.1371/journal.pone.0129813
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    References listed on IDEAS

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    1. Gerda Egger & Gangning Liang & Ana Aparicio & Peter A. Jones, 2004. "Epigenetics in human disease and prospects for epigenetic therapy," Nature, Nature, vol. 429(6990), pages 457-463, May.
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