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Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity

Author

Listed:
  • Yoshiro Toyama
  • Kiminobu Tanizawa
  • Takeshi Kubo
  • Yuichi Chihara
  • Yuka Harada
  • Kimihiko Murase
  • Masanori Azuma
  • Satoshi Hamada
  • Takefumi Hitomi
  • Tomohiro Handa
  • Toru Oga
  • Tsutomu Chiba
  • Michiaki Mishima
  • Kazuo Chin

Abstract

Rationale: Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention. Objectives: To investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences. Methods: Studied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography. Results: Although the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) ≥25 kg/m2 or visceral fat area ≥100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation

Suggested Citation

  • Yoshiro Toyama & Kiminobu Tanizawa & Takeshi Kubo & Yuichi Chihara & Yuka Harada & Kimihiko Murase & Masanori Azuma & Satoshi Hamada & Takefumi Hitomi & Tomohiro Handa & Toru Oga & Tsutomu Chiba & Mic, 2015. "Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    • Handle: RePEc:plo:pone00:0129513
    DOI: 10.1371/journal.pone.0129513
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