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A Prospective Monitoring Study of Cytomegalovirus Infection in Non-Immunosuppressed Critical Heart Surgery Patients

Author

Listed:
  • Paula Lopez Roa
  • Maria Jesus Perez-Granda
  • Patricia Munoz
  • Pilar Catalan
  • Roberto Alonso
  • Eduardo Sanchez-Perez
  • Emma Novoa
  • Emilio Bouza

Abstract

Background: Reactivation of cytomegalovirus (CMV) has been reported occasionally in immnunocompetent patients in the intensive care unit (ICU). The epidemiology and association of CMV infection with adverse outcome is not well defined in this population. Patients undergoing major heart surgery (MHS) are at a particularly high risk of infection. CMV infection has not been systematically monitored in MSH-ICU patients. Methods: We assessed CMV plasma viremia weekly using a quantitative polymerase chain reaction assay in a prospective cohort of immunocompetent adults admitted to the MHS-ICU for at least 72 hours between October 2012 and May 2013. Risk factors for CMV infection and its potential association with continued hospitalization or death by day 30 (composited endpoint) were assessed using univariate and multivariate logistic regression analyses. Results: CMV viremia at any level was recorded in 16.5% of patients at a median of 17 days (range, 3-54 days) after admission to the MHS-ICU. Diabetes (adjusted OR, 5.6; 95% CI, 1.8-17.4; p=0.003) and transfusion requirement (>10 units) (adjusted OR, 13.7; 95% CI, 3.9-47.8; p

Suggested Citation

  • Paula Lopez Roa & Maria Jesus Perez-Granda & Patricia Munoz & Pilar Catalan & Roberto Alonso & Eduardo Sanchez-Perez & Emma Novoa & Emilio Bouza, 2015. "A Prospective Monitoring Study of Cytomegalovirus Infection in Non-Immunosuppressed Critical Heart Surgery Patients," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0129447
    DOI: 10.1371/journal.pone.0129447
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