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A Meta-Analysis of Concurrent Chemoradiotherapy for Advanced Esophageal Cancer

Author

Listed:
  • Li-Li Zhu
  • Ling Yuan
  • Hui Wang
  • Lin Ye
  • Gui-Ying Yao
  • Cui Liu
  • Niu-Niu Sun
  • Xiao-Jing Li
  • Shi-Cong Zhai
  • Ling-Juan Niu
  • Jun-Bo Zhang
  • Hong-Long Ji
  • Xiu-Min Li

Abstract

Background: Concurrent chemoradiotherapy is a standard treatment for local advanced esophageal cancer, but the outcomes are controversial. Our goals were to compare the therapeutic effects of concurrent chemoradiotherapy and radiotherapy alone in local advanced esophageal cancer using meta-analysis. Methods: MEDLINE, EMBASE and the Cochrane library were searched for studies comparing chemoradiotherapy with radiotherapy alone for advanced esophageal cancer. Only randomized controlled trials were included, and extracted data were analyzed with Review Manager Version 5.2. The pooled relative risks (RR) and their 95% confidence intervals (CI) were calculated for statistical analysis. Results: Nine studies were included. Of 1,135 cases, 612 received concurrent chemoradiotherapy and 523 were treated with radiotherapy alone. The overall response rate (complete remission and partial remission) was 93.4% for concurrent chemoradiotherapy and 83.7% for radiotherapy alone (P = 0.05). The RR values of 1-year, 3-year, and 5-year survival rates were 1.14 (95% CI: 1.04 - 1.24, P = 0.006), 1.66 (95% CI: 1.34 - 2.06, P

Suggested Citation

  • Li-Li Zhu & Ling Yuan & Hui Wang & Lin Ye & Gui-Ying Yao & Cui Liu & Niu-Niu Sun & Xiao-Jing Li & Shi-Cong Zhai & Ling-Juan Niu & Jun-Bo Zhang & Hong-Long Ji & Xiu-Min Li, 2015. "A Meta-Analysis of Concurrent Chemoradiotherapy for Advanced Esophageal Cancer," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-13, June.
    • Handle: RePEc:plo:pone00:0128616
    DOI: 10.1371/journal.pone.0128616
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