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Androgen Receptor (AR), E-Cadherin, and Ki-67 as Emerging Targets and Novel Prognostic Markers in Triple-Negative Breast Cancer (TNBC) Patients

Author

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  • Giuseppina Rosaria Rita Ricciardi
  • Barbara Adamo
  • Antonio Ieni
  • Luana Licata
  • Roberta Cardia
  • Giuseppa Ferraro
  • Tindara Franchina
  • Giovanni Tuccari
  • Vincenzo Adamo

Abstract

Background: TNBC is an aggressive subset of breast cancer (BC) without specific target therapy. Methods: This observational, retrospective study included 45 cases of TNBC. The aim of this study was to evaluate the expression of the AR, E-cadherin and Ki-67 in relation to histological type, time to relapse and overall survival (OS). Immunohistochemistry (IHC) was carried out on formalin-fixed paraffin-embedded tumor samples obtained from patients defined TNBC. Results: The AR was positive (IHC >10%) in 26.6%. E-cadherin (CDH1) expression was considered positive if the score was ≥ 2. This expression was negative in 53.3% cases. The Ki-67 index was ≥ 20% in 37.7%. Univariate analyses showed that AR, CDH1 and Ki-67 are significantly associated with OS. Multivariate analysis showed that AR and Ki-67 expression are independent variables associated with OS. The statistical analysis showed that patients with AR negative and Ki-67 positive expression have a significant correlation with poor outcome. Conclusions: Our data suggest that the combination of AR and E-cadherin expression as well as Ki-67 status might be useful prognostic markers in TNBC. Hence, these molecular determinants could play an interesting role to classify subgroups of TNBC.

Suggested Citation

  • Giuseppina Rosaria Rita Ricciardi & Barbara Adamo & Antonio Ieni & Luana Licata & Roberta Cardia & Giuseppa Ferraro & Tindara Franchina & Giovanni Tuccari & Vincenzo Adamo, 2015. "Androgen Receptor (AR), E-Cadherin, and Ki-67 as Emerging Targets and Novel Prognostic Markers in Triple-Negative Breast Cancer (TNBC) Patients," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0128368
    DOI: 10.1371/journal.pone.0128368
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    Cited by:

    1. Li Chen & Liu Yang & Feng Qiao & Xin Hu & Shan Li & Ling Yao & Xue-Li Yang & Zhi-Ming Shao, 2015. "High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-14, October.

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