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Efficacy of Deferoxamine in Animal Models of Intracerebral Hemorrhage: A Systematic Review and Stratified Meta-Analysis

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  • Han-Jin Cui
  • Hao-yu He
  • A-Li Yang
  • Hua-Jun Zhou
  • Cong Wang
  • Jie-Kun Luo
  • Yuan Lin
  • Tao Tang

Abstract

Intracerebral hemorrhage (ICH) is a subtype of stroke associated with high morbidity and mortality rates. No proven treatments are available for this condition. Iron-mediated free radical injury is associated with secondary damage following ICH. Deferoxamine (DFX), a ferric-iron chelator, is a candidate drug for the treatment of ICH. We performed a systematic review of studies involving the administration of DFX following ICH. In total, 20 studies were identified that described the efficacy of DFX in animal models of ICH and assessed changes in the brain water content, neurobehavioral score, or both. DFX reduced the brain water content by 85.7% in animal models of ICH (-0.86, 95% CI: -.48- -0.23; P

Suggested Citation

  • Han-Jin Cui & Hao-yu He & A-Li Yang & Hua-Jun Zhou & Cong Wang & Jie-Kun Luo & Yuan Lin & Tao Tang, 2015. "Efficacy of Deferoxamine in Animal Models of Intracerebral Hemorrhage: A Systematic Review and Stratified Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0127256
    DOI: 10.1371/journal.pone.0127256
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