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Alterations of Gray and White Matter Networks in Patients with Obsessive-Compulsive Disorder: A Multimodal Fusion Analysis of Structural MRI and DTI Using mCCA+jICA

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  • Seung-Goo Kim
  • Wi Hoon Jung
  • Sung Nyun Kim
  • Joon Hwan Jang
  • Jun Soo Kwon

Abstract

Many of previous neuroimaging studies on neuronal structures in patients with obsessive-compulsive disorder (OCD) used univariate statistical tests on unimodal imaging measurements. Although the univariate methods revealed important aberrance of local morphometry in OCD patients, the covariance structure of the anatomical alterations remains unclear. Motivated by recent developments of multivariate techniques in the neuroimaging field, we applied a fusion method called “mCCA+jICA” on multimodal structural data of T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of 30 unmedicated patients with OCD and 34 healthy controls. Amongst six highly correlated multimodal networks (p

Suggested Citation

  • Seung-Goo Kim & Wi Hoon Jung & Sung Nyun Kim & Joon Hwan Jang & Jun Soo Kwon, 2015. "Alterations of Gray and White Matter Networks in Patients with Obsessive-Compulsive Disorder: A Multimodal Fusion Analysis of Structural MRI and DTI Using mCCA+jICA," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-23, June.
    • Handle: RePEc:plo:pone00:0127118
    DOI: 10.1371/journal.pone.0127118
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