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Carotid Intima-Media Thickness, a Marker of Subclinical Atherosclerosis, and Particulate Air Pollution Exposure: the Meta-Analytical Evidence

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  • Eline B Provost
  • Narjes Madhloum
  • Luc Int Panis
  • Patrick De Boever
  • Tim S Nawrot

Abstract

Introduction: Studies on the association between atherosclerosis and long-term exposure to ambient air pollution suggest that carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is positively associated with particulate matter (PM) exposure. However, there is heterogeneity between the different studies concerning the magnitude of this association. We performed a meta-analysis to determine the strength of the association between CIMT and particulate air pollution. Methods: We queried PubMed citation database and Web of Knowledge up to March 2015 in order to identify studies on CIMT and particulate air pollution. Two investigators selected and computerized all relevant information, independently. Eight of the reviewed epidemiological publications provided sufficient details and met our inclusion criteria. Descriptive and quantitative information was extracted from each selected study. The meta-analysis included 18,349 participants from eight cohorts for the cross-sectional association between CIMT and PM and 7,268 participants from three cohorts for the longitudinal analysis on CIMT progression and PM exposure. Results: The average exposure to PM2.5 in the different study populations ranged from 4.1 to 20.8 µg/m3 and CIMT averaged (SD) 0.73 (0.14) mm. We computed a pooled estimate from a random-effects model. In the combined cross-sectional studies, an increase of 5 µg/m3 PM2.5 was associated with a 1.66% (95% CI: 0.86 to 2.46; P

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  • Eline B Provost & Narjes Madhloum & Luc Int Panis & Patrick De Boever & Tim S Nawrot, 2015. "Carotid Intima-Media Thickness, a Marker of Subclinical Atherosclerosis, and Particulate Air Pollution Exposure: the Meta-Analytical Evidence," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0127014
    DOI: 10.1371/journal.pone.0127014
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    Cited by:

    1. Prakash Thangavel & Duckshin Park & Young-Chul Lee, 2022. "Recent Insights into Particulate Matter (PM 2.5 )-Mediated Toxicity in Humans: An Overview," IJERPH, MDPI, vol. 19(12), pages 1-22, June.

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