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Distinct Roles of Urinary Liver-Type Fatty Acid-Binding Protein in Non-Diabetic Patients with Anemia

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  • Naohiko Imai
  • Takashi Yasuda
  • Atsuko Kamijo-Ikemori
  • Yugo Shibagaki
  • Kenjiro Kimura

Abstract

Background: Various stresses including ischemia are known to up-regulate renal L-FABP gene expression and increase the urinary excretion of L-FABP. In diabetic patients with anemia, the urinary excretion of L-FABP is significantly increased. We studied the clinical significance of urinary L-FABP and its relationship with anemia in non-diabetic patients. Subjects and Methods: A total of 156 patients were studied in this retrospective cross-sectional analysis. The associations between anemia and urinary L-FABP levels, and the predictors of urinary L-FABP levels in non-diabetic patients were evaluated. Results: Urinary L-FABP levels were significantly higher in patients with anemia compared to those in patients without anemia. Similarly, the urinary L-FABP levels were significantly higher in patients with albuminuria compared to those in patients without albuminuria. Urinary L-FABP levels correlated with urinary albumin-to-creatinine ratios, estimated glomerular filtration rates, body mass index, and hemoglobin levels. Multivariate linear regression analysis determined that hemoglobin levels (β = -0.249, P = 0.001) and urinary albumin-to-creatinine ratios (β = 0.349, P

Suggested Citation

  • Naohiko Imai & Takashi Yasuda & Atsuko Kamijo-Ikemori & Yugo Shibagaki & Kenjiro Kimura, 2015. "Distinct Roles of Urinary Liver-Type Fatty Acid-Binding Protein in Non-Diabetic Patients with Anemia," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-8, May.
    • Handle: RePEc:plo:pone00:0126990
    DOI: 10.1371/journal.pone.0126990
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