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Neutrophil-to-Lymphocyte Ratio Is Associated with Impaired Interferon-Gamma Release to Phytohemagglutinin

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  • Kwang-Sook Woo
  • Byoung-Gwon Kim
  • Jae-Lim Choi
  • Bo-Ram Kim
  • Kyeong-Hee Kim

Abstract

Objective: The neutrophil-to-lymphocyte ratio (NLR) has been shown to predict adverse outcomes in several pathologic conditions. The majority of indeterminate interferon (IFN)-γ release assays were due to inadequate IFN-γ response to the phytohemagglutinin. We sought to study the value of NLR to predict an indeterminate result of QuantiFERON-TB Gold In-Tube (QFT-GIT) performed in routine laboratory practice. Methods: Results from 2,773 QFT-GIT assays were analyzed. Data collection included demographic data, the level of IFN-γ to nil, mitogen, and TB antigen of QFT-GIT, total WBC, and a differential count. We calculated the absolute neutrophil count, lymphocyte count, and NLR. Results: Of the total, 224 (8.1%) indeterminate results were observed. Twelve (1.8%) showed indeterminate results in the NLR range from 1.71 to 2.84, but 132 (19.2%) had indeterminate results in NLR≥5.18 (p

Suggested Citation

  • Kwang-Sook Woo & Byoung-Gwon Kim & Jae-Lim Choi & Bo-Ram Kim & Kyeong-Hee Kim, 2015. "Neutrophil-to-Lymphocyte Ratio Is Associated with Impaired Interferon-Gamma Release to Phytohemagglutinin," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0125794
    DOI: 10.1371/journal.pone.0125794
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