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Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression

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  • Rehana Kader
  • Rajen Govender
  • Soraya Seedat
  • John Randy Koch
  • Charles Parry

Abstract

The objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA.

Suggested Citation

  • Rehana Kader & Rajen Govender & Soraya Seedat & John Randy Koch & Charles Parry, 2015. "Understanding the Impact of Hazardous and Harmful Use of Alcohol and/or Other Drugs on ARV Adherence and Disease Progression," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0125088
    DOI: 10.1371/journal.pone.0125088
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    Cited by:

    1. Emmanuel Peprah & Bronwyn Myers & Andre-Pascal Kengne & Nasheeta Peer & Omar El-Shahawy & Temitope Ojo & Barbara Mukasa & Oliver Ezechi & Juliet Iwelunmor & Nessa Ryan & Fatoumata Sakho & John Patena , 2022. "Using a Syndemics Framework to Understand How Substance Use Contributes to Morbidity and Mortality among People Living with HIV in Africa: A Call to Action," IJERPH, MDPI, vol. 19(3), pages 1-12, January.
    2. Maria Y. Charumbira & Karina Berner & Quinette A. Louw, 2022. "Functioning Problems Associated with Health Conditions with Greatest Disease Burden in South Africa: A Scoping Review," IJERPH, MDPI, vol. 19(23), pages 1-30, November.

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