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Serum Immunoglobulin M Concentration Varies with Triglyceride Levels in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study

Author

Listed:
  • Hongbin Shi
  • Xiaoyan Guo
  • Qing Zhang
  • Hongmei Wu
  • Huanmin Du
  • Li Liu
  • Chongjin Wang
  • Yang Xia
  • Xing Liu
  • Chunlei Li
  • Shaomei Sun
  • Xing Wang
  • Ming Zhou
  • Qiyu Jia
  • Honglin Zhao
  • Kun Song
  • Dianjun Wei
  • Kaijun Niu

Abstract

Persistent low-grade inflammation is thought to underlie the pathogenesis of many chronic diseases, such as cardiovascular diseases and metabolic syndrome. Autoimmunity is correlated with increased levels of chronic low-grade inflammation, and immunoglobulin M (IgM) is reactive to autoantigens and believed to be important for autoimmunity. Triglyceride (TG) is fatty acid carrier and initiator of oxidative stress, and it has been hypothesized that TG stimulates B cells to secrete IgM. However, few studies have investigated the relationship between TG and IgM in human populations. We designed a cross-sectional and prospective cohort study to evaluate how serum TG levels are related to IgM concentration. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n = 10,808) and a prospective assessment (n = 2,615) were performed. Analysis of covariance was used in the cross-sectional analysis. After multiple adjustments for confounding factors, serum IgM level in the highest quartile of TG in males was significantly higher than levels in lower quartiles (P

Suggested Citation

  • Hongbin Shi & Xiaoyan Guo & Qing Zhang & Hongmei Wu & Huanmin Du & Li Liu & Chongjin Wang & Yang Xia & Xing Liu & Chunlei Li & Shaomei Sun & Xing Wang & Ming Zhou & Qiyu Jia & Honglin Zhao & Kun Song , 2015. "Serum Immunoglobulin M Concentration Varies with Triglyceride Levels in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0124255
    DOI: 10.1371/journal.pone.0124255
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