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Effects of Thiazolidinedione Therapy on Inflammatory Markers of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials

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  • Rui Chen
  • Jinchuan Yan
  • Peijing Liu
  • Zhongqun Wang

Abstract

Background: Inflammation is a common feature in patients with type 2 diabetes mellitus (T2DM). This meta-analysis aimed to assess the influence of thiazolidinedione (TZD) therapy on the circulating levels of inflammatory markers in patients with T2DM. Methods and Results: We searched the databases Medline, Embase, ScienceDirect, Web of Science, SpringerLink, and the Cochrane Library for randomized controlled trials (RCTs) that examined the effects of thiazolidinedione vs. a placebo on patients with T2DM. The main outcomes were absolute changes in levels of circulating inflammatory markers. Twenty-seven RCTs were included and data were analyzed using a fixed-effect model or a random-effect model based on heterogeneity. Pooled results indicated that circulating levels of high-sensitivity C reactive protein (hsCRP; SMD = –0.65, 95% CI = –0.98 to –0.32, p

Suggested Citation

  • Rui Chen & Jinchuan Yan & Peijing Liu & Zhongqun Wang, 2015. "Effects of Thiazolidinedione Therapy on Inflammatory Markers of Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0123703
    DOI: 10.1371/journal.pone.0123703
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