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Factors Associated with Methadone Treatment Duration: A Cox Regression Analysis

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  • Chao-Kuang Lin
  • Chia-Chun Hung
  • Ching-Yi Peng
  • En Chao
  • Tony Szu-Hsien Lee

Abstract

This study examined retention rates and associated predictors of methadone maintenance treatment (MMT) duration among 128 newly admitted patients in Taiwan. A semi-structured questionnaire was used to obtain demographic and drug use history. Daily records of methadone taken and test results for HIV, HCV, and morphine toxicology were taken from a computerized medical registry. Cox regression analyses were performed to examine factors associated with MMT duration. MMT retention rates were 80.5%, 68.8%, 53.9%, and 41.4% for 3, 6, 12, and 18 months, respectively. Excluding 38 patients incarcerated during the study period, retention rates were 81.1%, 73.3%, 61.1%, and 48.9% for 3 months, 6 months, 12 months, and 18 months, respectively. No participant seroconverted to HIV and 1 died during the 18-months follow-up. Results showed that being female, imprisonment, a longer distance from house to clinic, having a lower methadone dose after 30 days, being HCV positive, and in the New Taipei city program predicted early patient dropout. The findings suggest favorable MMT outcomes of HIV seroincidence and mortality. Results indicate that the need to minimize travel distance and to provide programs that meet women’s requirements justify expansion of MMT clinics in Taiwan.

Suggested Citation

  • Chao-Kuang Lin & Chia-Chun Hung & Ching-Yi Peng & En Chao & Tony Szu-Hsien Lee, 2015. "Factors Associated with Methadone Treatment Duration: A Cox Regression Analysis," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0123687
    DOI: 10.1371/journal.pone.0123687
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    Cited by:

    1. Bach Xuan Tran & Long Hoang Nguyen & Tung Thanh Tran & Carl A Latkin, 2018. "Social and structural barriers for adherence to methadone maintenance treatment among Vietnamese opioid dependence patients," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-13, January.
    2. Shaokun Liu & Xia Zou & Xiaoling Huang & Yin Liu & Qian Lu & Li Ling, 2019. "The Association between Living Status Transitions, Behavior Changes and Family Relationship Improvement among Methadone Maintenance Treatment Participants in Guangdong, China," IJERPH, MDPI, vol. 17(1), pages 1-13, December.
    3. Aisling Máire O’Connor & Gráinne Cousins & Louise Durand & Joe Barry & Fiona Boland, 2020. "Retention of patients in opioid substitution treatment: A systematic review," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-23, May.

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