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Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction

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  • Dan Zhu
  • Hong Xie
  • Xinyu Wang
  • Ying Liang
  • Haiyi Yu
  • Wei Gao

Abstract

Catestatin is a peptide which is a potent inhibitor of catecholamine secretion and played essential functions in the cardiovascular system. Previous research found that dramatic changes of catestatin were associated with hemodynamics in acute myocardial infarction (AMI) during the first week after the AMI symptoms onset, but whether catestatin is also involved in the pathophysiological progression after AMI and then a predictor for outcomes is not clear. The aim of this study is to determine the correlation of plasma catestatin levels at different time points and the prognosis of AMI. 100 participants recruited were all patients with AMI, all of who received successful primary percutaneous coronary intervention (PCI) within 12h from the AMI symptom onset in our center; the concentrations of plasma catestatin were evaluated from blood samples of those 100 participants. Subsequent 65 months' follow-up was performed after discharging to evaluate cardiac adverse events and the association between catestatin levels and prognosis of AMI was examined. We confirmed the dramatic change of catestatin concentrations in the first week of AMI, and the levels of catestatin on D3 were much higher in adverse events group than those in non-adverse events group (p

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  • Dan Zhu & Hong Xie & Xinyu Wang & Ying Liang & Haiyi Yu & Wei Gao, 2015. "Correlation of Plasma Catestatin Level and the Prognosis of Patients with Acute Myocardial Infarction," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0122993
    DOI: 10.1371/journal.pone.0122993
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