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Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

Author

Listed:
  • Karen Ann Ribbons
  • Patrick McElduff
  • Cavit Boz
  • Maria Trojano
  • Guillermo Izquierdo
  • Pierre Duquette
  • Marc Girard
  • Francois Grand’Maison
  • Raymond Hupperts
  • Pierre Grammond
  • Celia Oreja-Guevara
  • Thor Petersen
  • Roberto Bergamaschi
  • Giorgio Giuliani
  • Michael Barnett
  • Vincent van Pesch
  • Maria-Pia Amato
  • Gerardo Iuliano
  • Marcela Fiol
  • Mark Slee
  • Freek Verheul
  • Edgardo Cristiano
  • Ricardo Fernandez-Bolanos
  • Maria-Laura Saladino
  • Maria Edite Rio
  • Jose Cabrera-Gomez
  • Helmut Butzkueven
  • Erik van Munster
  • Leontien Den Braber-Moerland
  • Daniele La Spitaleri
  • Alessandra Lugaresi
  • Vahid Shaygannejad
  • Orla Gray
  • Norma Deri
  • Raed Alroughani
  • Jeannette Lechner-Scott

Abstract

Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS. Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P

Suggested Citation

  • Karen Ann Ribbons & Patrick McElduff & Cavit Boz & Maria Trojano & Guillermo Izquierdo & Pierre Duquette & Marc Girard & Francois Grand’Maison & Raymond Hupperts & Pierre Grammond & Celia Oreja-Guevar, 2015. "Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0122686
    DOI: 10.1371/journal.pone.0122686
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