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3D Evaluation of the Lamina Cribrosa with Swept-Source Optical Coherence Tomography in Normal Tension Glaucoma

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Listed:
  • Kazuko Omodaka
  • Takaaki Horii
  • Seri Takahashi
  • Tsutomu Kikawa
  • Akiko Matsumoto
  • Yukihiro Shiga
  • Kazuichi Maruyama
  • Tetsuya Yuasa
  • Masahiro Akiba
  • Toru Nakazawa

Abstract

Purpose: Although the lamina cribrosa (LC) is the primary site of axonal damage in glaucoma, adequate methods to image and measure it are currently lacking. Here, we describe a noninvasive, in vivo method of evaluating the LC, based on swept-source optical coherence tomography (SS-OCT), and determine this method’s ability to quantify LC thickness. Methods: This study comprised 54 eyes, including normal (n = 18), preperimetric glaucoma (PPG; n = 18), and normal tension glaucoma (NTG; n = 18) eyes. We used SS-OCT to obtain 3 x 3 mm cube scans of an area centered on the optic disc, and then synchronized reconstructed B- and en-face images from this data. We identified the LC in these B-scan images by marking the visible borders of the LC pores. We marked points on the anterior and posterior borders of the LC in 12 B-scan images in order to create a skeleton model of the LC. Finally, we used B-spline interpolation to form a 3D model of the LC, including only reliably measured scan areas. We calculated the average LC thickness (avgLCT) in this model and used Spearman's rank correlation coefficient to compare it with circumpapillary retinal nerve fiber layer thickness (cpRNFLT). Results: We found that the correlation coefficient of avgLCT and cpRNFLT was 0.64 (p

Suggested Citation

  • Kazuko Omodaka & Takaaki Horii & Seri Takahashi & Tsutomu Kikawa & Akiko Matsumoto & Yukihiro Shiga & Kazuichi Maruyama & Tetsuya Yuasa & Masahiro Akiba & Toru Nakazawa, 2015. "3D Evaluation of the Lamina Cribrosa with Swept-Source Optical Coherence Tomography in Normal Tension Glaucoma," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-16, April.
    • Handle: RePEc:plo:pone00:0122347
    DOI: 10.1371/journal.pone.0122347
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    Cited by:

    1. Kazuko Omodaka & Seri Takahashi & Akiko Matsumoto & Shigeto Maekawa & Tsutomu Kikawa & Noriko Himori & Hidetoshi Takahashi & Kazuichi Maruyama & Hiroshi Kunikata & Masahiro Akiba & Toru Nakazawa, 2016. "Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-18, April.

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