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Prognostic Significance of Matrix Metalloproteinase-7 in Gastric Cancer Survival: A Meta-Analysis

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  • Saeed Soleyman-Jahi
  • Saharnaz Nedjat
  • Afshin Abdirad
  • Niloofar Hoorshad
  • Reza Heidari
  • Kazem Zendehdel

Abstract

The prognostic role of matrix metalloproteinase-7 in gastric cancer survival has been widely evaluated. However, the results are controversial. We aimed to set up a meta-analysis to reach a conclusion on the prognostic significance of metalloproteinase-7 in gastric cancer survival as well as its association with clinicopathological parameters. We searched popular databases from 1988 until October 2014 to gather eligible peer-reviewed papers addressing the prognostic effect of matrix metalloproteinase-7 in gastric cancer patients' survival. The CASP check list was used for quality appraisal. Pooled hazard ratio (HR) for survival and odds ratio (OR) for association with their 95% confidence interval (CI) were considered as summary measurements. Finally, 1208 gastric cancer patients from nine studies were included in the meta-analysis. Pooled HR estimate for survival was 2.01 (95% CI = 1.62 – 2.50, P

Suggested Citation

  • Saeed Soleyman-Jahi & Saharnaz Nedjat & Afshin Abdirad & Niloofar Hoorshad & Reza Heidari & Kazem Zendehdel, 2015. "Prognostic Significance of Matrix Metalloproteinase-7 in Gastric Cancer Survival: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-17, April.
    • Handle: RePEc:plo:pone00:0122316
    DOI: 10.1371/journal.pone.0122316
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