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Image Analyzer-Based Assessment of Tumor-Infiltrating T Cell Subsets and Their Prognostic Values in Colorectal Carcinomas

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  • Younghoon Kim
  • Jeong Mo Bae
  • Gang Li
  • Nam Yun Cho
  • Gyeong Hoon Kang

Abstract

To find useful tools to evaluate the prognosis in colorectal carcinoma (CRC) patients, we investigated the prognostic values of tumor-infiltrating T lymphocyte subsets according to intratumoral subsites as well as clinical or molecular characteristics. Immunohistochemistry for CD8, CD45RO, and FOXP3 was performed, and densities of the T cell subsets in each tissue microarray core (cells/mm2) were measured by image analysis. In the training set (n = 218) of CRC, T cell subset densities in the invasion front were more strongly associated with patient outcome than those in the tumor center. In the validation set (n = 549), T cell subset densities in the invasion front were evaluated. Univariate analysis showed that all three T cell subset densities were significantly associated with longer progression free survival and overall survival time (p

Suggested Citation

  • Younghoon Kim & Jeong Mo Bae & Gang Li & Nam Yun Cho & Gyeong Hoon Kang, 2015. "Image Analyzer-Based Assessment of Tumor-Infiltrating T Cell Subsets and Their Prognostic Values in Colorectal Carcinomas," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-16, April.
    • Handle: RePEc:plo:pone00:0122183
    DOI: 10.1371/journal.pone.0122183
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    1. Charles R. Mackay, 1999. "Dual personality of memory T cells," Nature, Nature, vol. 402(6763), pages 3-4, December.
    2. Charles R. Mackay, 1999. "Dual personality of memory T cells," Nature, Nature, vol. 401(6754), pages 659-660, October.
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