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Morbidity and Mortality According to Latest CD4+ Cell Count among HIV Positive Individuals in South Africa Who Enrolled in Project Phidisa

Author

Listed:
  • Patrick H Maduna
  • Matt Dolan
  • Lwando Kondlo
  • Honey Mabuza
  • Judith N Dlamini
  • Mike Polis
  • Thabo Mnisi
  • Susan Orsega
  • Patrick Maja
  • Lotty Ledwaba
  • Thuthukile Molefe
  • Phumelele Sangweni
  • Lisette Malan
  • Gugu Matchaba
  • Paul Khabo
  • Greg Grandits
  • James D Neaton

Abstract

Background: Short-term morbidity and mortality rates for HIV positive soldiers in the South African National Defence Force (SANDF) would inform decisions about deployment and HIV disease management. Risks were determined according to the latest CD4+ cell count and use of antiretroviral therapy (ART) for HIV positive individuals in the SANDF and their dependents. Methods and Findings: A total of 7,114 participants were enrolled and followed for mortality over a median of 4.7 years (IQR: 1.9, 7.1 years). For a planned subset (5,976), progression of disease (POD) and grade 4, potentially life-threatening events were also ascertained. CD4+ count and viral load were measured every 3 to 6 months. Poisson regression was used to compare event rates by latest CD4+ count (

Suggested Citation

  • Patrick H Maduna & Matt Dolan & Lwando Kondlo & Honey Mabuza & Judith N Dlamini & Mike Polis & Thabo Mnisi & Susan Orsega & Patrick Maja & Lotty Ledwaba & Thuthukile Molefe & Phumelele Sangweni & Lise, 2015. "Morbidity and Mortality According to Latest CD4+ Cell Count among HIV Positive Individuals in South Africa Who Enrolled in Project Phidisa," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-20, April.
    • Handle: RePEc:plo:pone00:0121843
    DOI: 10.1371/journal.pone.0121843
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