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MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

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Listed:
  • Mancheng Gong
  • Wenjing Dong
  • Tingyu He
  • Zhirong Shi
  • Guiying Huang
  • Rui Ren
  • Sichong Huang
  • Shaopeng Qiu
  • Runqiang Yuan

Abstract

Background and Objectives: Methylenetetrahydrofolate reductase (MTHFR) polymorphism may be a risk factor for male infertility. However, the epidemiologic studies showed inconsistent results regarding MTHFR polymorphism and the risk of male infertility. Therefore, we performed a meta-analysis of published case-control studies to re-examine the controversy. Methods: Electronic searches of PubMed, EMBASE, Google Scholar and China National Knowledge Infrastructure (CNKI) were conducted to select eligible literatures for this meta-analysis (updated to June 19, 2014). According to our inclusion criteria and the Newcastle-Ottawa Scale (NOS), only high quality studies that observed the association between MTHFR polymorphism and male infertility risk were included. Crude odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of association between the MTHFR polymorphism and male infertility risk. Results: Twenty-six studies involving 5,575 cases and 5,447 controls were recruited. Overall, MTHFR 677C>T polymorphism showed significant associations with male infertility risk in both fixed effects (CT+TT vs. CC: OR = 1.34, 95% CI: 1.23–1.46) and random effects models (CT+TT vs. CC: OR = 1.39, 95% CI: 1.19–1.62). Further, when stratified by ethnicity, sperm concentration and control sources, the similar results were observed in Asians, Caucasians, Azoo or OAT subgroup and both in population-based and hospital-based controls. Nevertheless, no significant association was only observed in oligo subgroup. Conclusions: Our results indicated that the MTHFR polymorphism is associated with an increased risk of male infertility. Further well-designed analytical studies are necessary to confirm our conclusions and evaluate gene-environment interactions with male infertility risk.

Suggested Citation

  • Mancheng Gong & Wenjing Dong & Tingyu He & Zhirong Shi & Guiying Huang & Rui Ren & Sichong Huang & Shaopeng Qiu & Runqiang Yuan, 2015. "MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-17, March.
  • Handle: RePEc:plo:pone00:0121147
    DOI: 10.1371/journal.pone.0121147
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    Cited by:

    1. Zhengju Ren & Pengwei Ren & Bo Yang & Kun Fang & Shangqing Ren & Jian Liao & Shengzhuo Liu & Liangren Liu & Zhufeng Peng & Qiang Dong, 2017. "MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.
    2. Himanshu Rai & Nakul Sinha & Sudeep Kumar & Ajay Kumar Sharma & Suraksha Agrawal, 2016. "Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-25, April.

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