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External Validation of Fatty Liver Index for Identifying Ultrasonographic Fatty Liver in a Large-Scale Cross-Sectional Study in Taiwan

Author

Listed:
  • Bi-Ling Yang
  • Wen-Chieh Wu
  • Kuan-Chieh Fang
  • Yuan-Chen Wang
  • Teh-Ia Huo
  • Yi-Hsiang Huang
  • Hwai-I Yang
  • Chien-Wei Su
  • Han-Chieh Lin
  • Fa-Yauh Lee
  • Jaw-Ching Wu
  • Shou-Dong Lee

Abstract

Background and Aims: The fatty liver index (FLI) is an algorithm involving the waist circumference, body mass index, and serum levels of triglyceride and gamma-glutamyl transferase to identify fatty liver. Although some studies have attempted to validate the FLI, few studies have been conducted for external validation among Asians. We attempted to validate FLI to predict ultrasonographic fatty liver in Taiwanese subjects. Methods: We enrolled consecutive subjects who received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009. Ultrasonography was applied to diagnose fatty liver. The ability of the FLI to detect ultrasonographic fatty liver was assessed by analyzing the area under the receiver operating characteristic (AUROC) curve. Results: Among the 29,797 subjects enrolled in this study, fatty liver was diagnosed in 44.5% of the population. Subjects with ultrasonographic fatty liver had a significantly higher FLI than those without fatty liver by multivariate analysis (odds ratio 1.045; 95% confidence interval, CI 1.044–1.047, p

Suggested Citation

  • Bi-Ling Yang & Wen-Chieh Wu & Kuan-Chieh Fang & Yuan-Chen Wang & Teh-Ia Huo & Yi-Hsiang Huang & Hwai-I Yang & Chien-Wei Su & Han-Chieh Lin & Fa-Yauh Lee & Jaw-Ching Wu & Shou-Dong Lee, 2015. "External Validation of Fatty Liver Index for Identifying Ultrasonographic Fatty Liver in a Large-Scale Cross-Sectional Study in Taiwan," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0120443
    DOI: 10.1371/journal.pone.0120443
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    1. Yuan-Lung Cheng & Yuan-Jen Wang & Wei-Yu Kao & Ping-Hsien Chen & Teh-Ia Huo & Yi-Hsiang Huang & Keng-Hsin Lan & Chien-Wei Su & Wan-Leong Chan & Han-Chieh Lin & Fa-Yauh Lee & Jaw-Ching Wu, 2013. "Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease: A Large-Scale Study in Populations Seeking for Check-Up," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-9, August.
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