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The Influence of Maternal Islet Beta-Cell Autoantibodies in Conjunction with Gestational Hyperglycemia on Neonatal Outcomes

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  • Li Zhe
  • Wu Tian-mei
  • Ming Wei-jie
  • Chen Xin
  • Xiao Xiao-min

Abstract

Objective: To determine the predictive value of the presence of maternal islet beta-cell autoantibodies with respect to neonatal outcomes. Methods: A total of 311 pregnant women with abnormal 75 g oral glucose tolerance test (OGTT) results were enrolled in this study. Maternal glutamic acid decarboxylase autoantibodies (GADA), islet cell autoantibodies (ICA) and insulin autoantibodies (IAA) were tested in fasting blood both on the day following the routine OGTT and before delivery. The birth weight, Apgar score, blood glucose and outcomes of each neonate were later evaluated and recorded. Results: 1. In this study, 33.9% of the pregnant women with gestational hyperglycemia had detectable levels of one or more types of anti-islet cell antibodies in the third trimester. The proportion of women who produced GADA and/or ICA was significantly higher in the group of women with gestational hyperglycemia than in the control group (P

Suggested Citation

  • Li Zhe & Wu Tian-mei & Ming Wei-jie & Chen Xin & Xiao Xiao-min, 2015. "The Influence of Maternal Islet Beta-Cell Autoantibodies in Conjunction with Gestational Hyperglycemia on Neonatal Outcomes," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0120414
    DOI: 10.1371/journal.pone.0120414
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