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Cardiac Microvascular Barrier Function Mediates the Protection of Tongxinluo against Myocardial Ischemia/Reperfusion Injury

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Listed:
  • Kang Qi
  • Lujin Li
  • Xiangdong Li
  • Jinglin Zhao
  • Yang Wang
  • Shijie You
  • Fenghuan Hu
  • Haitao Zhang
  • Yutong Cheng
  • Sheng Kang
  • Hehe Cui
  • Lian Duan
  • Chen Jin
  • Qingshan Zheng
  • Yuejin Yang

Abstract

Objective: Tongxinluo (TXL) has been shown to decrease myocardial necrosis after ischemia/reperfusion (I/R) by simulating ischemia preconditioning (IPC). However, the core mechanism of TXL remains unclear. This study was designed to investigate the key targets of TXL against I/R injury (IRI) among the cardiac structure-function network. Materials and Methods: To evaluate the severity of lethal IRI, a mathematical model was established according to the relationship between myocardial no-reflow size and necrosis size. A total of 168 mini-swine were employed in myocardial I/R experiment. IRI severity among different interventions was compared and IPC and CCB groups were identified as the mildest and severest groups, respectively. Principal component analysis was applied to further determine 9 key targets of IPC in cardioprotection. Then, the key targets of TXL in cardioprotection were confirmed. Results: Necrosis size and no-reflow size fit well with the Sigmoid Emax model. Necrosis reduction space (NRS) positively correlates with I/R injury severity and necrosis size (R2=0.92, R2=0.57, P 0.05) or CCB (P

Suggested Citation

  • Kang Qi & Lujin Li & Xiangdong Li & Jinglin Zhao & Yang Wang & Shijie You & Fenghuan Hu & Haitao Zhang & Yutong Cheng & Sheng Kang & Hehe Cui & Lian Duan & Chen Jin & Qingshan Zheng & Yuejin Yang, 2015. "Cardiac Microvascular Barrier Function Mediates the Protection of Tongxinluo against Myocardial Ischemia/Reperfusion Injury," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-24, March.
  • Handle: RePEc:plo:pone00:0119846
    DOI: 10.1371/journal.pone.0119846
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    1. Sara M. Weis & David A. Cheresh, 2005. "Pathophysiological consequences of VEGF-induced vascular permeability," Nature, Nature, vol. 437(7058), pages 497-504, September.
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