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A Permutation Test for Oligoset DNA Pooling Studies

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  • Hsiao-Yuan Huang
  • Jui-Hsiang Lin
  • Wen-Chung Lee

Abstract

Case-control association studies often suffer from population stratification bias. A previous triple combination strategy of stratum matching, genomic controlling, and multiple DNA pooling can correct the bias and save genotyping cost. However the method requires researchers to prepare a multitude of DNA pools—more than 30 case-control pooling sets in total (polyset). In this paper, the authors propose a permutation test for oligoset DNA pooling studies. Monte-Carlo simulations show that the proposed test has a type I error rate under control and a power comparable to that of individual genotyping. For a researcher on a tight budget, oligoset DNA pooling is a viable option.

Suggested Citation

  • Hsiao-Yuan Huang & Jui-Hsiang Lin & Wen-Chung Lee, 2015. "A Permutation Test for Oligoset DNA Pooling Studies," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0119096
    DOI: 10.1371/journal.pone.0119096
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