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Research Activity and the Association with Mortality

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  • Baris A Ozdemir
  • Alan Karthikesalingam
  • Sidhartha Sinha
  • Jan D Poloniecki
  • Robert J Hinchliffe
  • Matt M Thompson
  • Jonathan D Gower
  • Annette Boaz
  • Peter J E Holt

Abstract

Introduction: The aims of this study were to describe the key features of acute NHS Trusts with different levels of research activity and to investigate associations between research activity and clinical outcomes. Methods: National Institute for Health Research (NIHR) Comprehensive Clinical Research Network (CCRN) funding and number of patients recruited to NIHR Clinical Research Network (CRN) portfolio studies for each NHS Trusts were used as markers of research activity. Patient-level data for adult non-elective admissions were extracted from the English Hospital Episode Statistics (2005-10). Risk-adjusted mortality associations between Trust structures, research activity and, clinical outcomes were investigated. Results: Low mortality Trusts received greater levels of funding and recruited more patients adjusted for size of Trust (n = 35, 2,349 £/bed [95% CI 1,855–2,843], 5.9 patients/bed [2.7–9.0]) than Trusts with expected (n = 63, 1,110 £/bed, [864–1,357] p

Suggested Citation

  • Baris A Ozdemir & Alan Karthikesalingam & Sidhartha Sinha & Jan D Poloniecki & Robert J Hinchliffe & Matt M Thompson & Jonathan D Gower & Annette Boaz & Peter J E Holt, 2015. "Research Activity and the Association with Mortality," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-15, February.
  • Handle: RePEc:plo:pone00:0118253
    DOI: 10.1371/journal.pone.0118253
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    References listed on IDEAS

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    1. Panagiotis N Papanikolaou & Georgia D Christidi & John P A Ioannidis, 2006. "Patient Outcomes with Teaching Versus Nonteaching Healthcare: A Systematic Review," PLOS Medicine, Public Library of Science, vol. 3(9), pages 1-13, September.
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