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Increased Risk of Cutaneous Melanoma Associated with p53 Arg72Pro Polymorphism

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  • Peiliang Geng
  • Yunmei Liao
  • Zhihua Ruan
  • Houjie Liang

Abstract

Objective: The objective of this study was to test the hypothesis that p53 Arg72Pro polymorphism may contribute to an increased risk of cutaneous melanoma (CM). Methods: By searching the databases of PubMed, EMBASE, and Web of Science, a total of 8 eligible case-control studies with 1,957 CM cases and 2,887 controls were included in this meta-analysis. Stata software was used to analyze all the statistical data. Results: The pooled data by a fixed-effects model suggested an increased risk of CM associated with p53 Arg72Pro polymorphism under the genetic model of Arg/Pro vs. Pro/Pro without heterogeneity (ORArg/Pro vs. Pro/Pro = 1.76, 95% CI = 1.55-1.99, Pheterogeneity = 0.075). A similar trend was seen in subgroups of hospital-based studies and population-based studies. Conclusion: Our meta-analysis based on all studies shows that the p53 Arg72Pro polymorphism may increase individual susceptibility to CM, particularly in Caucasians and could serve as a biomarker to predict the population at high risk of CM.

Suggested Citation

  • Peiliang Geng & Yunmei Liao & Zhihua Ruan & Houjie Liang, 2015. "Increased Risk of Cutaneous Melanoma Associated with p53 Arg72Pro Polymorphism," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0118112
    DOI: 10.1371/journal.pone.0118112
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