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A Comparison between the Sixth and Seventh Editions of the UICC/AJCC Staging System for Nasopharyngeal Carcinoma in a Chinese Cohort

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Listed:
  • Jing Li
  • Xiong Zou
  • Yun-Long Wu
  • Jing-Cui Guo
  • Jing-Ping Yun
  • Miao Xu
  • Qi-Sheng Feng
  • Li-Zhen Chen
  • Jin-Xin Bei
  • Yi-Xin Zeng
  • Ming-Yuan Chen

Abstract

Background: The International Union Against Cancer/American Joint Committee on Cancer (UICC/AJCC) TNM staging system of nasopharyngeal carcinoma (NPC) is the most important system for survival prediction. The TNM 7th edition UICC/AJCC TNM staging system for NPC was adopted in January 2009, and is now internationally recommended. In comparison with the TNM 6th edition, there were several revisions in the new edition staging system. This study aims to evaluate the prognostic value of the TNM 7th edition for NPC patients in comparison with the TNM 6th edition. Method: Clinical data of 2,629 NPC patients from the Sun Yat-sen University Cancer Center between January 2006 and December 2010 were retrospectively collected and all the patients were restaged according to the criteria of the TNM 6th edition and TNM 7th edition UICC/AJCC staging manual. Univariate and multivariate COX proportional hazards analyses were applied to evaluate the prognostic values between adjacent stage categories of the TNM 6th edition and TNM 7th edition. Results: In comparison with the TNM 6th edition, a significant alteration of the distribution of N categories was observed when the TNM 7th edition was applied (χ2 = 20.589, P

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  • Jing Li & Xiong Zou & Yun-Long Wu & Jing-Cui Guo & Jing-Ping Yun & Miao Xu & Qi-Sheng Feng & Li-Zhen Chen & Jin-Xin Bei & Yi-Xin Zeng & Ming-Yuan Chen, 2014. "A Comparison between the Sixth and Seventh Editions of the UICC/AJCC Staging System for Nasopharyngeal Carcinoma in a Chinese Cohort," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-20, December.
    • Handle: RePEc:plo:pone00:0116261
    DOI: 10.1371/journal.pone.0116261
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    Cited by:

    1. Yong-Qiao He & Tong-Min Wang & Mingfang Ji & Zhi-Ming Mai & Minzhong Tang & Ruozheng Wang & Yifeng Zhou & Yuming Zheng & Ruowen Xiao & Dawei Yang & Ziyi Wu & Changmi Deng & Jiangbo Zhang & Wenqiong Xu, 2022. "A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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