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Urinary Excretion of Fatty Acid-Binding Protein 4 is Associated with Albuminuria and Renal Dysfunction

Author

Listed:
  • Yusuke Okazaki
  • Masato Furuhashi
  • Marenao Tanaka
  • Tomohiro Mita
  • Takahiro Fuseya
  • Shutaro Ishimura
  • Yuki Watanabe
  • Kyoko Hoshina
  • Hiroshi Akasaka
  • Hirofumi Ohnishi
  • Hideaki Yoshida
  • Shigeyuki Saitoh
  • Kazuaki Shimamoto
  • Tetsuji Miura

Abstract

Background: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is expressed in not only adipocytes and macrophages but also peritubular capillaries in the normal kidney. We recently demonstrated that ectopic expression of FABP4, but not FABP1 known as liver FABP (L-FABP), in the glomerulus is associated with progression of proteinuria and renal dysfunction. However, urinary excretion of FABP4 has not been investigated. Methods: Subjects who participated in the Tanno-Sobetsu Study, a study with a population-based cohort design, in 2011 (n = 392, male/female: 166/226) were enrolled. Urinary FABP4 (U-FABP4) and urinary albumin-to-creatinine ratio (UACR) were measured. Change in estimated glomerular filtration rate (eGFR) was followed up one year later. Results: In 93 (23.7%) of the 392 subjects, U-FABP4 level was below the sensitivity of the assay. Subjects with undetectable U-FABP4 were younger and had lower UACR and higher eGFR levels than subjects with measurable U-FABP4. U-FABP4 level was positively correlated with age, systolic blood pressure and levels of serum FABP4 (S-FABP4), triglycerides, hemoglobin A1c (HbA1c), urinary FABP1 (U-FABP1) and UACR (r = 0.360, p

Suggested Citation

  • Yusuke Okazaki & Masato Furuhashi & Marenao Tanaka & Tomohiro Mita & Takahiro Fuseya & Shutaro Ishimura & Yuki Watanabe & Kyoko Hoshina & Hiroshi Akasaka & Hirofumi Ohnishi & Hideaki Yoshida & Shigeyu, 2014. "Urinary Excretion of Fatty Acid-Binding Protein 4 is Associated with Albuminuria and Renal Dysfunction," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0115429
    DOI: 10.1371/journal.pone.0115429
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    1. Shutaro Ishimura & Masato Furuhashi & Yuki Watanabe & Kyoko Hoshina & Takahiro Fuseya & Tomohiro Mita & Yusuke Okazaki & Masayuki Koyama & Marenao Tanaka & Hiroshi Akasaka & Hirofumi Ohnishi & Hideaki, 2013. "Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-7, November.
    2. Masato Furuhashi & Shutaro Ishimura & Hideki Ota & Manabu Hayashi & Takahiro Nishitani & Marenao Tanaka & Hideaki Yoshida & Kazuaki Shimamoto & Gökhan S Hotamisligil & Tetsuji Miura, 2011. "Serum Fatty Acid-Binding Protein 4 Is a Predictor of Cardiovascular Events in End-Stage Renal Disease," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-6, November.
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