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The Value of Routine Biopsy during Percutaneous Kyphoplasty for Vertebral Compression Fractures

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  • Qiang Li
  • Surong Hua
  • Chu Wang
  • Siyi Cai
  • Jia Zhang

Abstract

Objective: Percutaneous kyphoplasty (PKP) is now widely performed to treat VCF, which is usually caused by osteoporosis. Previous researches have reported unsuspected malignancies found by biopsy. However, the safety and cost-effective profiles of routine biopsy during PKP are unclear. The purpose of this study was to evaluate the feasibility of routine biopsy during PKP in treatment of VCF. Methods: Ninety-three patients (September 2007–November 2010) undergoing PKP without biopsy were reviewed as the control group. One hundred and three consecutive patients (November 2010–September 2013) undergoing PKP with biopsy of every operated vertebral level were prospectively enrolled as the biopsy group. The rate of unsuspected lesions was reported, and the severe adverse events, surgical duration, cement leakage rate and pain control were compared between the two groups. Results: No statistically significant differences were found between the two groups, regarding the severe adverse events, surgical duration, cement leakage rate and pain control. Four unsuspected lesions were found in the biopsy group, three of which were malignancies with a 2.9% (3/103) unsuspected malignancy rate. The economic analysis showed that routine biopsy was cost-effective in finding new malignancies comparing with a routine cancer screening campaign. Conclusions: Routine biopsy during PKP was safe and cost-effective in finding unsuspected malignancies. We advocate routine biopsy in every operated vertebral level during PKP for VCF patients.

Suggested Citation

  • Qiang Li & Surong Hua & Chu Wang & Siyi Cai & Jia Zhang, 2014. "The Value of Routine Biopsy during Percutaneous Kyphoplasty for Vertebral Compression Fractures," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-9, December.
    • Handle: RePEc:plo:pone00:0115417
    DOI: 10.1371/journal.pone.0115417
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    References listed on IDEAS

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    1. Avram Edidin & Kevin Ong & Edmund Lau & Jordana Schmier & Jason Kemner & Steven Kurtz, 2012. "Cost-Effectiveness Analysis of Treatments for Vertebral Compression Fractures," Applied Health Economics and Health Policy, Springer, vol. 10(4), pages 273-284, July.
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