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Meta-Analysis of the Prognostic Value of Smad4 Immunohistochemistry in Various Cancers

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  • Yiping Du
  • Xin Zhou
  • Zebo Huang
  • Tianzhu Qiu
  • Jian Wang
  • Wei Zhu
  • Tongshan Wang
  • Ping Liu

Abstract

Background: Accumulating evidence indicates that Smad4 (DPC4) plays a fundamental role in the development and prognosis of several types of cancer. The objective of this study was to conduct a meta-analysis to evaluate whether the loss of Smad4 staining could serve as a prognostic marker. Methods: A comprehensive meta-analysis was conducted using major useful databases to determine the relationship between the immunohistochemical detection of Smad4 and the survival of patients with various cancers. We used hazard ratios (HRs) with 95% confidence interval (CIs) as the effect estimation to evaluate the association of Smad4 with overall survival (OS), cancer-specific survival (CSS) or recurrence-free survival (RFS). The relationship between the clinical characteristics of patients and Smad4 was also evaluated using the odds ratio (OR). Results: A total of 7570 patients from 26 studies were included in the analysis. The pooled results showed that loss of Smad4 staining was a negative predictor of OS with an HR of 1.97 (95% CI: 1.55–2.51; Pheterogeneity

Suggested Citation

  • Yiping Du & Xin Zhou & Zebo Huang & Tianzhu Qiu & Jian Wang & Wei Zhu & Tongshan Wang & Ping Liu, 2014. "Meta-Analysis of the Prognostic Value of Smad4 Immunohistochemistry in Various Cancers," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0110182
    DOI: 10.1371/journal.pone.0110182
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    Cited by:

    1. Wei Xu & Sau Har Lee & Fengjun Qiu & Li Zhou & Xiaoling Wang & Tingjie Ye & Xudong Hu, 2021. "Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysis," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-14, May.

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