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The Prevalence of Primary Angle Closure Glaucoma in Adult Asians: A Systematic Review and Meta-Analysis

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  • Jin-Wei Cheng
  • Ying Zong
  • You-Yan Zeng
  • Rui-Li Wei

Abstract

Background: Primary angle closure glaucoma (PACG) is higher in Asians than Europeans and Africans, with over 80% of PACG worldwide in Asia. Previous estimates of PACG were based largely on early studies, mostly using inappropriate case definitions. Therefore, we did a systematic review and meta-analysis to estimate the prevalence of PACG in adult Asian populations and to quantify its association with age, gender, and region. Methods: All primary reports of population-based studies that reported the prevalence of PACG in adult Asian populations were identified. PACG case definition was compatible with the ISGEO definition. Twenty-nine population-based studies were included. The overall pooled prevalence estimates were calculated using a random effect model, and ethnicity-, age- and gender-specific pooled prevalence estimates were also calculated. Results: The overall pooled prevalence of PACG in those of adult Asians was 0.75% (95% CI, 0.58, 0.96). Ethnicity-specific pooled prevalence estimates were 0.97% (0.22, 4.27) in Middle East group, 0.66% (0.23, 1.86) in South East Asia group, 0.46% (0.32, 0.64) in India group, 1.10% (0.85, 1.44) in China group, and 1.19% (0.35, 3.98) in Japan group, respectively. Age-specific prevalence was 0.21% (0.12, 0.37) for those 40–49 years, 0.54% (0.34, 0.85) for those 50–59 years, 1.26% (0.93, 1.71) for those 60–69 years, and 2.32% (1.74, 3.08) for those 70 years or above. The overall female to male ratio of the PACG prevalence was 1.51∶1 (95% CI 1.01, 2.28). Conclusions: PACG affects approximately 0.75% adult Asians, increasing double per decade, and 60% of cases being female. The prevalence rates vary greatly by ethnic region.

Suggested Citation

  • Jin-Wei Cheng & Ying Zong & You-Yan Zeng & Rui-Li Wei, 2014. "The Prevalence of Primary Angle Closure Glaucoma in Adult Asians: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-9, July.
  • Handle: RePEc:plo:pone00:0103222
    DOI: 10.1371/journal.pone.0103222
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    1. Štefanija Kolačko & Jurica Predović & Antonio Kokot & Damir Bosnar & Vlatka Brzović-Šarić & Borna Šarić & Slaven Balog & Kristina Milanovic & Domagoj Ivastinovic, 2021. "Do Gender, Age, Body Mass and Height Influence Eye Biometrical Properties in Young Adults? A Pilot Study," IJERPH, MDPI, vol. 18(21), pages 1-10, November.
    2. Hui-Chen Cheng & Chao-Yu Guo & Yu-Jing Chen & Mei-Ju Chen & Yu-Chieh Ko & Nicole Huang & Catherine Jui-ling Liu, 2016. "Patient-Reported Vision-Related Quality-of-Life Differences between Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-12, September.
    3. Xueli Chen & Yuhong Chen & Janey L Wiggs & Louis R Pasquale & Xinghuai Sun & Bao Jian Fan, 2016. "Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-11, June.
    4. Shenghong Li & Ping Li & Honghan Gong & Fei Jiang & Dan Liu & Fengqin Cai & Chonggang Pei & Fuqing Zhou & Xianjun Zeng, 2017. "Intrinsic Functional Connectivity Alterations of the Primary Visual Cortex in Primary Angle-Closure Glaucoma Patients before and after Surgery: A Resting-State fMRI Study," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-16, January.

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