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Methylenetetrahydrofolate Reductase C677T Polymorphism and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis of 29 Case-Control Studies

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  • Bo Zhu
  • Xiaomei Wu
  • Xueyuan Zhi
  • Lei Liu
  • Quanmei Zheng
  • Guifan Sun

Abstract

Background: Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, had significant effects on the homocysteine levels. The common functional MTHFR C677T polymorphism had been extensively researched. Several studies had evaluated the relationship between MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM), but the results were still controversial in the Chinese Han population. This meta-analysis was conducted to evaluate the relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. Methods: We searched the relevant studies in multiple electronic databases, which published up to December 2013. We reviewed and extracted data from all the included studies on the relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) were used to evaluate the relationship. Fixed-effects and random-effects meta-analysis were used to pool ORs by the heterogeneity. Publication bias and sensitivity analysis were also examined. Results: 29 studies were finally included in our meta-analysis, which contained 4656 individuals with T2DM and 2127 healthy controls. There was a significant relationship between MTHFR C677T polymorphism and T2DM under dominant (OR: 1.70, 95% CI: 1.42–2.02), recessive (OR: 1.48, 95% CI: 1.21–1.80), homozygous (OR: 1.89, 95% CI: 1.47–2.42), heterozygous (OR: 1.58, 95% CI: 1.33–1.87), and additive (OR: 1.46, 95% CI: 1.28–1.68) genetic model in a random-effects model. Subgroup analysis also reached similar results. Sensitivity analysis indicated that the overall result were dependable. Conclusions: There was a significant relationship between MTHFR C677T polymorphism and T2DM in the Chinese Han population. The results of our meta-analysis suggested that MTHFR 677T allele might be a risk genetic factor of T2DM in the Chinese Han population.

Suggested Citation

  • Bo Zhu & Xiaomei Wu & Xueyuan Zhi & Lei Liu & Quanmei Zheng & Guifan Sun, 2014. "Methylenetetrahydrofolate Reductase C677T Polymorphism and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis of 29 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0102443
    DOI: 10.1371/journal.pone.0102443
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    References listed on IDEAS

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    1. Jian-Hong Zhong & A Chapin Rodríguez & Na-Na Yang & Le-Qun Li, 2013. "Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Type 2 Diabetes Mellitus," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-11, September.
    2. Wei Wang & Yujia Wang & Fangqi Gong & Weihua Zhu & Songling Fu, 2013. "MTHFR C677T Polymorphism and Risk of Congenital Heart Defects: Evidence from 29 Case-Control and TDT Studies," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
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    Cited by:

    1. Bo Zhu & Xiaomei Wu & Kang Ning & Feng Jiang & Lu Zhang, 2016. "The Negative Relationship between Bilirubin Level and Diabetic Retinopathy: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-16, August.
    2. Xueyuan Zhi & Boyi Yang & Shujun Fan & Yongfang Li & Miao He & Da Wang & Yanxun Wang & Jian Wei & Quanmei Zheng & Guifan Sun, 2016. "Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes," IJERPH, MDPI, vol. 13(12), pages 1-11, December.

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