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Association between PTEN Gene IVS4 Polymorphism and Risk of Cancer: A Meta-Analysis

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  • Liping Sun
  • Jingwei Liu
  • Quan Yuan
  • Chengzhong Xing
  • Yuan Yuan

Abstract

Background: Phosphatase and tensin homolog (PTEN) is a well established tumor suppressor gene. Recently, increasing studies investigated the association between PTEN IVS4 polymorphism (rs3830675) and risk of various types of cancer. However, the results from the individual studies were controversial. The aim of this meta-analysis was to elucidate whether PTEN IVS4 polymorphism was associated with cancer risk. Methods: Databases including PubMed, Web of knowledge and Chinese National Knowledge Infrastructure (CNKI) were systematically searched to identify potentially eligible literatures. Odds ratios (OR) and their 95% confidence interval (CI) were used to assess the strength of association between PTEN IVS4 polymorphism and cancer risk. Results: A total of seven case-control studies were finally included in this meta-analysis. The pooled analysis suggested that individuals with PTEN IVS4 (−/−) genotype were significantly associated with increased risk of cancer (OR = 1.45, 95% CI = 1.19–1.76, P

Suggested Citation

  • Liping Sun & Jingwei Liu & Quan Yuan & Chengzhong Xing & Yuan Yuan, 2014. "Association between PTEN Gene IVS4 Polymorphism and Risk of Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0098851
    DOI: 10.1371/journal.pone.0098851
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    Cited by:

    1. Lu Tang & Xintao Li & Yu Gao & Luyao Chen & Liangyou Gu & Jianwen Chen & Xiangjun Lyu & Yu Zhang & Xu Zhang, 2017. "Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-14, July.

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